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Silver is widely diffused but is rarely found in the native state.

Silver is originally as widespread as gold, occurring in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nearly all of the volcanic rocks. Whereas gold remains unaltered by the action of the elements and is often carried long dis

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ances from its original place of occurrence, silver on the contrary is only to be found in the rocks where it originally occu

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s. When these rocks are broken down or worn away, the silver is either driven into new mineral combinations, or more often di

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ssipated and lost. Silver, therefore, is only to be obtained by subterranean mining. Shafts are driven and the ore brought to

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

the surface, and by use of various processes the silver is extracted, refined and made ready for commercial purposes.

An old

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

process and one still employed extensively throughout Mexico where a large quantity of silver is produced, is to take the ore

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

after it has been crushed or reduced to a fine mud or puddle and spread it about two feet deep over the floor of a large cou

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

tyard. Powered sulfate of copper is spread over the mass and then horses or mules are driven around in circle to tread the s

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lfate in and mix it thoroughly with the ore. After about one day’s treading a quantity of common salt is added and after two

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ays more treading quicksilver is added. This mass is trodden over for a period of about fifteen days, and is then shoveled in

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

to a large tank through which a rapid stream of water is passed. This washes away all but the silver and quicksilver, which i

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

then poured into cone-shaped canvas bags. Most of the quicksilver runs out leaving the silver, which is then retorted. The q

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

icksilver is used over and over again to assist in recovering the silver.

Pure silver has a beautiful white color and luster

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

; it is almost as plastic as pure gold and like it very soft. Silver does not tarnish in natural air, but when it comes in co

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

tact with sulfur compounds it readily forms black silver sulfide. The sulfur compounds which act on silver are found in small

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

quantities in the air as a result of burning coal and illuminating gas, while larger amounts occur in vulcanized rubber, wool

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

, and foods like eggs.

Pure silver is too soft to make durable objects that require lightness and stability of form. This de

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ect is overcome by alloying it with a little copper.

An alloy of 925 parts fine silver and 75 parts copper is called 925-100

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

fine or what is commonly known as sterling silver. This alloy is used almost universally for jewelry and the best silverware

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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