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Reading history of world heroes such as; Socrates, Plato, Aristotle, Ghandy, Alexander the Great,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

former kings of the Kingdom of Cambodia, Chuon Nat (Cambodian), Nou Korn (Cambodian), presidents o

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

the United States of America and villains such as, Pol Pot, Khieu Samphan and Nuon Chea, has insp

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ired me to fulfill one thing: leaving my human traces in this world as much as possible.

One of t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e extremely systematic philosophical questions that, until today no one can reasonable provide the

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

answer yet, is why life? This article intends to answer this philosophical question and that answ

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

r is: “to remain human traces in this world as much as possible.”

To me, life is just about strug

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

gling to remain our human traces in this world as much as possible. This article is not to persuad

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the readers to the theological, scientific, or other extreme paths, but just to solve one of the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

life’s questions.

We are all proud that we are the most intellectual species of any specie of ani

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

al on earth. Indeed, we are lucky and extremely lucky to live in human lifestyle, but have we ever

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

imagine that we will die in human ways or as animal’ behaviors? So try to live and to will die in

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

human behaviors.

I do not contradict your cash business and other competition for luxurious human

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

lifestyle, but do not forget to remain your human traces in this world as much as possible, becaus

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e we do not know, in term of religious or non-religious belief, whether we would be born human aga

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n or not; if we are to be born human again, we would see our former human traces and if we are to

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

be born animals, we would know that we used to be human and if we are not to be born again, our hu

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

an traces will still help our next generation: there is no any negative aspects behind remaining o

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ur human traces in this world.

“Reaming our human traces in this world as much as possible; a one

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

hundred percent perfect vocation.” Coined by Lay Vicheka (May 13, 2006, 11:10 p.m., Cambodian time

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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