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If you are preparing any kind of meals from a recipe, it's important that you understand the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

various methods of cooking. There are a number of terms for different ways of cooking, as f

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ollow.

Grilled

If a recipe calls for something to be grilled, it generally means it should

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

be cooked over an open flame or heat. Grilling can be done by charcoal or gas - on a barbeq

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e for example - or it can be done using a grill of some sort on the burners of your stove.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Broiled

Broiling indicates cooking by exposing directly to a heat source such as a flame or

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

element. Most ovens have a "broil" setting, which heats an element at the top of the stove

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ather than the one at the bottom, which is used for baking.

When broiling items in the oven

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

, they should normally be placed on the top rack to give them the proper heat exposure.

Fry

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ing vs Deep Frying

Both frying and deep-frying cook foods with a similar process, but the m

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

thod is a little different in each case. Frying can be done over any heat source, such as a

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

stove element or an open flame. Oil or butter is heated and the food is cooked by its heat.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Deep frying, on the other hand, also involves oil but in this case the food is completely s

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ubmerged in the oil. Deep frying is used for foods such as french fries, breaded chicken and

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

doughnuts. It can be dangerous, however, because you're dealing with boiling oil so proper e

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

quipment and safety precautions must be used.

Sauteing

Sauteing involved cooking food quic

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

kly in a small amount of fat. It is similar in process to frying, but because of the smaller

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

amount of fat and faster cooking times, it brings out stronger flavors than frying will.

Kn

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

owing what is involved with the various terms will make it easier to plan when following a r

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ecipe. You'll know what equipment and ingredients you'll need that are unique to each method

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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