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The origin of the fruit salad dates back to the 19th century, when it According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product was included in many menus from different countries. A fruit salad is ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug. Examples of combination products may in dish comprised of a variety of fruits served with a base sauce or in lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together. their own syrup. A fruit salad is usually served as a dessert. It is a here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe so served as an appetizer called a fruit cocktail. When served as a fr d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations. Combination pro it cocktail it is often prepared in an alcohol and sugar base. The fr ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc uits that form parts of a fruit salad vary from country to country. It easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi is determined by the seasonal availability of the fruits and where the nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically y are grown. Fruit salads often include apples, pineapples, pears, che and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ ries, grapes, kiwifruit, peaches and oranges. A fruit salad is an ext ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi emely nutritious dish that provides many vitamins and minerals needed ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it. Following aspects would a by the body. It is a wonderfully refreshing dish that provides instant dd to the challenges in developing combination products: Which markets to tap where the combination products can do fairly well? Which combination prod energy. The fruit salad has many variations as per the taste preferre cts are meaningful and rational? Which therapeutic categories to select? Which Combinations can address unmet needs of the patients? Do combin d in that particular country. In Northern Europe, fruit salad is serve tions increase the patient compliance? What would be the developing cost? How to tackle the risks encountered during combination product developmen with a mayonnaise base. Countries like Malaysia and Indonesia prefer t? As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel o have it with a spicier flavor. There are also other variations serve ping new procedures for reviewing their safety, efficacy and quality. Professional from academic institutions, pharmaceutical industries, health care indust d with yogurt or a sour cream base. A very common and popular way of s y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products rving the fruit salad in India is with ice cream. Fruit salad can be p . As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de repared with both fresh and canned fruits. It has thus, evolved into a elopment. They need to be wiser in analyzing the market trends and the regulatory requirements. Companies that provide selfless information through particip extremely popular dish fulfilling both nutritional and taste criteria tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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