Social Space - Cancer

A recent study suggested that eating tomatoes an

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

d broccoli together can enhance the anti-cancer

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

potentency possessed by tomatoes and broccoli.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

In the study, rats were injected with human pros

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

tate tumors. And they were fed powdered tomato a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nd dried broccoli. Used also in the study was fi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nasteride, a drug that shows to slow the benign

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

growth of the prostate.

The study found that th

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e rats use diets with tomatoes and or broccoli g

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

et the smaller tumors. The diet with both tomato

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es and broccoli is most effective and finasterid

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e is least effective in slowing the tumor growth

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

.

Tomatoes are known for its anti-cancer proper

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ties. Lycopene is believed to be the major activ

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e component in tomatoes that is responsible for

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

the anti-cancer activity.

Anti-cancer bioactivi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ty has been reported in broccoli. It's believed

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

that glucosinolates may be responsible.

The stu

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

dy was conducted by Dr. John Erdman and colleagu

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

es at University of Illinois at Urbana-Champaign

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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