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Bleh – fleas! ‘Tis the season – are you prepared? It’s not just at home where you need to be ready either. Different geograp

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

hical areas have different climate conditions so the flea season varies depending on where you are – keep that in mind wheth

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

r you are at home or traveling. Something else to be aware of is that fleas, in various stages of their disgusting lives, ca

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

survive indoors even during the cold weather. Following are some helpful facts about fleas and information on how you can p

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

event them from infesting your pets and your home.

Even though there are more than 2,000 known species and subspecies of fl

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

as, only one class of flea called the ‘cat flea’ is to blame for almost all the fleas found on cats and dogs in the United S

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ates. What is really daunting is that there is evidence of fleas dating all the way back to the dinosaur era which means the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

y obviously aren’t going away by themselves – all the more reason to do something to protect your pets and family.

Most fle

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

s can survive for an average of two to three months without ‘food’ which is actually the blood they suck from their ‘hosts’.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

A female flea consumes 15 times her own body weight in blood daily! You should also know that while adult fleas suck blood

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

rom a cat, dog or other mammal, their larvae live and feed on organic debris in the host animal's environment – that’s your

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ome! Be aware that some fleas can jump 150 times their own length – that compares to a human jumping 1,000 feet. So if you h

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ppen to see one flea, there may be more than 100 offspring or adults looming nearby in furniture, carpeting or on your pet.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Now let’s talk about how to prevent these gross little parasites from getting into your life and how to get rid of them if t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hey do. As a pet owner, one of your main responsibilities is to keep your pet healthy. Taking them to the vet for their annu

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

l check ups is very important. While you’re there, be sure to talk to your veterinarian about a flea prevention method for y

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ur furry friends such as Advantage, Advantix or Frontline. Certain products can also help to prevent ticks in addition to fl

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

as.

If you see fleas on your pets or in your home, take action immediately. Not only are fleas a huge annoyance, but they c

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

n also transmit diseases and tapeworm. If your home becomes infested, you will probably need to purchase flea bombs – make s

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

re read and adhere to the directions carefully and contact your vet to get further advice and relief for your pet and family

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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