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Betta is a popular tank fish and its maintenance is least painful. However, it does need car

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e and you must be observant about its heath. A sick Betta is easy to spot since naturally th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

fish is very active and vibrant. If you have had the fish for a while you will be able to s

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

pot immediately when they are unwell.

Following tips can help you keep the Betta ecosystem

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ealthy and vibrant:

1. A bowl large enough to allow ample swimming space is a prerequisite.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

The fish shouldn’t bump and tear its fins or scales. A large enough tank also ensures that t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

he water has adequate oxygen level.

2. These fish do not require filtration but need the cl

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

anest water you can provide them. Change the water every three days to keep it clean and avo

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

d infection in your fish. The water you add to the tank should have set out for 24 hours (ag

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ed water).

3. Bettas are also called Siamese fighting fish because the male of the species

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ill fight each other to death! Never put two males in the same tank. Females can stay togeth

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

r and so can one male with many females. You can also keep your Betta with algae eaters, gup

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

pies and corydorus catfish.

4. Ensure that the bottom of the bowl or tank is debris free. Y

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

u can use something as simple as a turkey baster to do this cleaning. Debris sitting at the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ottom will make the water cloudy and unhygienic for the fish. They will also cause the water

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

to smell.

5. Maintain the tank pH at 7.

6. When cleaning the tank accessories, avoid usin

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

soap because traces of soap will change the water pH.

7. Betta can jump out of tanks and b

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

wls, so keep them covered.

8. Betta is

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

not a fussy fish and will happily eat the Betta pellets and frozen bloodworms. However, Bet

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

as are fond of live food such as brine shrimp, and you must serve it as a treat now and then

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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