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Are you an avid fan of antique perfume bottles or thinking of starting your own collection? Here are some must-knows on buying antique pe

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

rfume bottles.

Firstly, do your homework on the perfume bottle styles, manufacturer and period that you are interested in. There are man

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

y books available on the market today that tell you about the history, unique bottle features of each era and price range of vintage bott

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

les. But there is also a wealth of such information provided free on the Internet, so that is a good place to start.

Secondly, what can

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

one find antique perfume bottles? Begin by searching antique stores if you are a newbie. Most storeowners would be able to guide you on t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

he age and origin of each piece. Compare what the storeowner tells you with your research note and you will know whether the storeowner i

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s reliable. Auction sites like Yahoo! and eBay are good for bargain purchases but make sure you ask lots of questions and demand to see p

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ictures of the bottle to ensure it is the real thing. You may also be able to unravel gems occasionally in garage or yard sales.

The man

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ufacturer of antique perfume bottles is important too. Some of the most famous manufacturers of perfume bottles are Lalique, Baccarat, Ju

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lian Viard, Devilbiss, Tiffany, Daum Nancy. To determine whether the antique perfume bottle is original, be sure to scrutinize the bottom

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of the bottle. Brands like Lalique and Baccarat mark their bottles, which make your collecting a lot easier.

Another consideration is t

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

he overall condition of the antique perfume bottle. The bottle should be in immaculate condition. After all, the condition of the perfume

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

bottle is one main determinant of its value. Check for chips, cracks, stains and scratches on the bottle. If the antique perfume bottle

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

comes with a label, is there any tear, blotches or fading?

Next, collectors are concerned about the contents in the bottles. Many collec

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

tors may wish to own antique perfume bottles that still contain the original scents. Indeed, perfumes that are sealed will fetch higher p

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

rices. But bear in mind that perfumes lose their freshness after 7 to 10 years, so some vintage perfumes actually stink! In addition, per

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

fumes evaporate over time due to the alcohol content and there may also be residue in the bottles.

Lastly, antique perfume bottles requi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

re special care. If your old perfume bottles are turning cloudy from hard water minerals, drop a denture-cleaning tablet in, fill the bot

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

tle with water and let the fizzing action clean it. The interior of perfume bottle can also be cleaned by swirling lead shot or sand arou

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nd in the water-filled bottle. Just take care not to over-fill the perfume bottle lest water comes into contact with and damage the label

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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