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A personal alarm is nothing more than a glorified siren. The theory behind it is relatively simple: if someone attacks, or the likelihood of

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

being attacked is very high, you simply switch it on and the personal security alarm will start screaming with an impressive 120 or 125 decib

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ls. If you are lucky enough, this will draw attention and the attacker will leave you alone.

Of course it is crucial that a person alarm can

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

not be stopped by an attacker. This is achieved by using a hidden switch that only the person owning it knows about. It is also crucial to un

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

erstand that a personal alarm only has a certain effectiveness. It will not always deter attackers. This is why non lethal weapons are common

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

y used in conjunction. Personal alarms and mace pepper spray make a very good combination and are also very effective in deterring attackers

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

from pursuing their course of action.

The personal safety alarms for personal protection are not the only way in which these can be used. Ch

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ld safety personal alarms have the same basic construction, but serve a very different purpose. They are usually there to ensure that if a ch

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ild gets lost; his parents will be able to locate him or her in the shortest amount of time.

Another interesting application of the personal

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

alarm is its usage in locating a person after a catastrophe, like a hurricane or earthquake. With the recent occurrence of such events it mig

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t not be too long until these will surpass in popularity the traditional personal safety alarms, pepper spray included. Obviously this would

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

only be true for those certain areas where this sort of event has a higher probability. The technology used by this new breed of personal ala

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ms is inspired by that used by skiers to protect against avalanches, which contain a GPS enabled beacon, and a loud siren which goes on inter

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

mittently (in order to preserve battery power). As technology will advance more still, it is quite possible that these devices will become mo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e and more effective.

The online market for devices such as the personal alarm has seen an explosive growth in the recent years. The offer t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ough is slightly limited. The size of the device is constantly decreasing and so are the performances, while the prices stay relatively fair.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

This happens as the competition is getting more fierce by the day, with more and more manufacturers joining this promising market.

Altogeth

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

r a personal alarm is a useful thing to have around. In conjunction with pepper spray it decreases your chances of getting harmed greatly and

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

in the case of a disaster it can quite literally save your life. Of course some areas are more dangerous than others. The decision to purcha

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e ultimately belongs to you, but it does seem a sensible thing to take precautions against these events even if the odds are relatively small

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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