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Air purifiers have been around in various forms since the 1940s, when the first HEPA filter was des

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

igned to protect workers from airborne nuclear material. Since then, air purifiers have been used i

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

n hospitals, work sites, and homes to protect against viruses, mold, bacteria, pollen, pet dander,

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tobacco smoke, dust mites, and a great number of industrial and household chemicals. The people who

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

stand the most to gain from air purifiers are those with allergies, asthma, and other respiratory

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ailments.

But everybody can benefit from having cleaner air in the home. The Environmental Protect

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ion Agency lists indoor air pollution among the top five environmental risks to public health. In f

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

act, the inside of your home could well contain two to one hundred times more air pollutants than a

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

n outdoor urban environment.

Air purifier value varies widely. You can spend upwards of $1600 for

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

the best air purifiers known to man, or you can spend as little as $70 for a good car unit. You can

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

also spend an arm and a leg on junk if you’re not careful. One thing to keep in mind when buying a

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

n air purifier is unit-to-filter value. If your unit uses a HEPA filter, find out how much it costs

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

to replace the filter. You may end up spending thousands on the filter alone. The question is, wha

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t kind of a machine do you want?

Home air purifiers use a number of technological approaches to cl

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

eaning your air so you can breathe more easily. They use HEPA (High Efficiency Particulate Air) fil

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ters; electrostatic filters, ion generators, ozone generators, ultraviolet light, and other methods

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

to get rid of both large and miniscule particles. Some operate by drawing in air via a fan, cleani

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ng the air, and re-releasing it. Others work by actually sending out “purifying agents” throughout

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the room.

Today you have two basic choices for home air purifiers: room air purifiers, and whole h

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ouse purifiers. Generally speaking, room purifiers are better for air-cleaning efficiency and cost.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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