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According to the Italian Tourism Board, there are about 40,000 hotels in Italy. That's a lot to choose from when you're traveling

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

from overseas. Whether you're planning to stay in a hotel in Venice or a hotel in Rome, here's what you should know when you mak

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e your Italian hotel reservations:

1. Pay your deposit - According to law, a hotel booking is valid upon payment of a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

deposit. Your deposit is refundable upon cancellation of your reservation at least 14 days in advance of your stay, or 30 days in

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

advance if you are going during tourist season.

2. Time your trip - In cities and resorts, the off-season is conside

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ed November through March. April, May, September, and November are considered the off-season for ski resorts. Rates for a hotel i

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

n Venezia or Roma will be less during the off season.

3. Hotel ratings - The tourism bureau gives hotels ratings from

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

one to five stars, with five stars signifying deluxe accommodations. Bed and breakfast accommodations are available throughout It

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

aly, but they are not given ratings.

4. Day hotels - If you're on the move and simply need a place to freshen up, Ital

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

y offers day hotels. With baths, showers, beauty salons, baggage checking, and private rooms, day hotels are often found in citie

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

and near train stations.

After you've made your Italian hotel reservations, paid your deposit, and arrive at your hot

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

el in Venice, your hotel in Rome, or another Italian destination, it's time to enjoy your vacation. The Italian Tourism Board pro

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

vides these tips to help ensure that your vacation is the memorable experience you deserve:

* Avoid counterfeit goods

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

- A new 2005 law imposes heavy fines on those who purchase counterfeit goods. If you're looking for knockoffs with luxury labels

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

, you may want to think twice. Purchasing such goods carries a fine of up to 10,000 Euros.

* Know the duty-free limit

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s - The U.S. allows citizens returning from Italy to bring in up to $400 worth of products duty free. A duty charge of ten percen

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

of the next $1,000 worth of goods will be assessed.

* No visa required - U.S. citizens staying in Italy fewer than 9

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

0 days do not need a visa.

* Registration required - Tourists are required to register with the police within three d

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ays of arrival. Hotels generally do this on behalf of their guests, but it's wise to double check when making your Italian hotel

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

reservations. If you're staying in a private home or with friends, you should go to the nearest police station to register.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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