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If you are on a guided African safari, your chances of encountering problems are minimal. Tour operators make it the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ir business to know the areas they travel in thus reducing risk to travellers. However, it is sensible to take norma

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

l precautions on your African safari, particularly when travelling through urban areas.

Travel Documents / Money

A

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

lways have a photocopy of your passport, and any visas. Also, have a list of traveller’s cheque numbers. These copie

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s should be packed separately from the originals. It is never a good idea to carry large amounts of cash, and most u

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

rban centres (hotels, shops) do accept credit cards (Visa and Mastercard are most common), and traveller’s cheques.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

You might need cash for purchases local markets – keep this in a travel wallet, or a zip pocket.

Luggage

Never le

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ave cameras and hand luggage unattended, whether in a vehicle, or even in a hotel foyer. Never pack valuables (this

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

includes medication), in your check-in luggage.

Personal Safety

When travelling independently on your African safa

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ri, stay informed in terms of the local news. Ask at your hotel about any unsafe areas, and codes of dress and behav

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

iour. Don't openly carry valuables. If you must carry your passport and money, keep them in a buttoned-down pocket.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Game Viewing

Your guide will always do a safety talk with you, whether your game viewing is to be done from a vehi

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

cle, or on foot. Wildlife is potentially dangerous, but as long as you adhere to what you guide tells you, there is

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

very little to worry about. At viewpoints, hides and camps, wildlife is more familiar with people and less intimida

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ted by your presence. Never tease or corner wild animals - this may cause an unpredictable response and a potentiall

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

y dangerous reaction. Never feed any animals, as this can cause them to lose their fear of humans.

Creepy Crawlies

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Although Africa is known to be home to a number of potentially dangerous species, especially snakes, scorpions, spi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ders, and insects, very few visitors are adversely affected. Snakes tend to be shy, and generally stay away from bui

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

lt-up areas. Lodges and camps generally have insect (especially mosquito) proofing in their rooms. If you go on a wa

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

lk, it is always a good idea to comfortable, enclosed walking shoes, socks, and long trousers – just as a precaution

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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The drug companies don't want you to know this, but they're quickly killing us. Want to find out how? Keep reading this eye opening expose.

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