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Traditional business jets, from Airbus, Boeing, Grumman or General Dynamics, Lear, or Lockheed could cost anywhere from a few million dollars to nearly $

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

40 million. The average cost was rarely less than $15 million. But that's changing. Even 40 years ago, the cost of a Lear Jet was over $1 million, in dol

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ars that today would be equivalent to $10 million or more.

Today, the Airbus A319 retails for around $35 million, some of the lower-end Lear jets sell f

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

or about $3 million, the the Avcraft Dornier 328 Envoy is in the middle range.

Under competitive pressure from Eclipse Aviation, and for other economica

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ly compelling reasons, several manufacturers have risen to the challenge of making cheaper biz jets.

Eclipse Aviation is leading the pack with its small

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

r, lighter-weight entry, the Eclipse E500. Retailing in the neighborhood of a clean $1 million, the six-seat jet is set to take off.

Production is rampi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ng up from a hundred to a planned output of over 1,000 planes over the next two years in the face of back orders of over 2,000 planes. At those prices, a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

suming continued FAA certification, those sales orders likely to remain healthy for some years to come. Considering that over 500 of those orders are for

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

owner-flown planes, the market is wide open.

At only 10,000 lbs (4,500 kg) these two engine wonders can make 350 knots and travel from Boston to Miami (

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

1,300 nautical miles) in a single hop. At a cost of 60 cents per mile to fly, these VLJ (Very Light Jets) are likely to wind up in a lot of smaller airpo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ts over the next ten years.

But the other manufacturers aren't sitting on the runway twiddling their thumbs.

Cessna has a smaller business jet (not tec

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nically considered a VLJ), the Citation Mustang, that is part of it's family of 4,500 business jets. The company has about 250 orders for the new model a

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

nd it is being positioned as an alternative for those looking for something less expensive than the average jet.

The six-person (two crew, four passenge

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

) plane is priced at around $2.55 million. That's the cost of an upscale house in Orange County, CA or Long Island, NY. (Being a millionaire isn't what i

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

used to be.)

Honda Motor Co will be bringing out its HondaJet, another VLJ, over the next year. No price has been set, but with the company's track rec

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ord of producing less expensive cars, motorcycles, etc, you can bet they'll be competitive.

The FAA predicts there will be 4,500 VLJ in service 10 years

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

from now, but even the FAA chief acknowledges that the estimate is a conservative one. You may not find one in your driveway then, but how far away is th

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nearest small airport?

When an average home in LA costs over $600,000 it isn't much of a stretch to imagine a few neighbors - tired of the hassle of co

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

mmercial airline travel - getting together and buying a private jet.

With falling production costs, and the increasing hassle of flying commercial airli

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

es, the air taxi market is likely to zoom up over the next few years. Business jets from Eclipse, Cessna, Honda, and others, are ready to meet the demand

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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