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This Friday morning the chirping tropical birds in the courtyard outside the building woke me up early. Vanessa had fixed a real Mexican breakfast: fruit – melon and papaya, with yoghurt and sweat bread. Appropriately strengthene

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

d we got going early at 8:45 to start exploring Mexicy City. Our explorations started with a ride on a public bus on the Eje Central, one of the main streets of Mexico City. It took us straight to “La Torre Latinoamericana”, Mexi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

co’s famous 44-story skyscraper. Completed in 1956, this skyscraper has survived a number of earthquakes, most notably the big earthquake of 1985 which destroyed big sections of Mexico City. From the cafeteria on the 42nd floor w

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e had a great 360 degree view over the city, although the smoggy atmosphere impeded our visibility.

After getting a good lay of the land, we descended and exited through the rear doors of la Torre Latinoamericana and realized th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

at a big exhibit of Rodin sculptures was in town. We saw a variety of statues by the famous French sculptor, including the Thinker. The environment behind the Torre Latinoamericana was also really interesting since some of the bu

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ldings right next to this skyscraper are in very bad repair and formed a very interesting backdrop to this exhibition. I assume that these buildings were damaged in the big earthquake of 1985. Our next stop was at the Palacio de

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Bellas Artes, an Art Nouveau style theatre or opera house. The interior holds murals by some of the famous Mexican artists of the 20th century, including Diego Rivera, Jos? Clemente Orozco, David Alfar Siqueiros and Rufino Tamayo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

. The Palacio was originally started in 1905 by an Italian architect, and was not completed until 1934 as the Mexican Revolution intervened. This explains the Art Deco interior of this fascinating building. We continued our walk

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

towards the Alameda Central – Mexico City’s famous park whose name is derived from the “alamos” or poplar trees that were planted here in the 16th century. The Alameda Central holds a variety of different statues, including one o

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

f Beethoven and one of Neptune. The most imposing monument is the so-called “Hemiciclo a Juarez”, a semi-circular marble monument dedicated to Mexico’s reformist president of indigenous background. A few steps away from the Alam

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

da Central we had a look at the Museo Mural Diego Rivera which exhibits one of Rivera’s greatest masterpieces: Dream of a Sunday Afternoon in the Alameda Central. This mural has huge dimensions and was originally created for the

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Hotel Prado and includes a lot of symbolism and references to Mexico’s history.

After taking in Diego Rivera’s huge mural we headed towards Mexico’s grandest street: The Paseo de la Reforma. This broad, tree-lined street was ori

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ginally laid out in the 1860s, during the short-lived reign of Emperor Maximilian. At the intersection with Avenida Benito Juarez is the Caballito (the “Little Horse”), one of the city’s landmarks. We continued on past the the Ho

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

tel Imperial to the Monumento a la Revoluci?n. This was dictator Porfirio Diaz’ unfinished congress building, that was later turned into a monument to the 1910 revolution by the people who got rid of him.

Then we passed back on

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Calle Juarez to the Casa de los Azulejos, the “House of Tiles” dating back to the 16th century. It features a beautiful Moorish-style interior and has been turned into a Sanborns restaurant. On the landing of the stairs between t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e first and second floor it features a mural by Jos? Clemente Orozco, which amazingly surrounds the bathrooms. We slowly made our way towards the Z?calo, first visiting the brand-new Museo de Arte Popular. It is housed in a histo

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ric building with a big courtyard that is located close to the Torre Latinoamericana and holds all sorts of typically Mexican artifacts, including traditional clothing, sombreros, decorations, silver work and various types of jew

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ellery as well as typical symbols of Mexico such as the Calaveras (the ever-popular and colourful skeletons so enjoyed by Mexicans).

We explored the local neighbourhood, visiting the one-street Chinatown, passed by a wonderful p

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

astry shop (la Dulcer?a Celaya) where Vanessa introduced me to delicious Mexican sweets and then we discovered Mexico’s biggest pawnshop: the government-run Nacional Monte de Piedad, a beautiful monumental building made of dark v

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

olcanic stone that dates back to the 16th century. We were both commenting on the irony that people in Mexico still like to buy and sell gold jewellery although for safety reasons they are not able to wear it openly on the street

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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