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Lesotho is otherwise known as the Kingdom in the Sky, because of its high altitude and mountain peaks, Lesotho offers the traveller a different face of Africa, which is closer to alpine in climate, scenery and vegetation. Invigorating mountain air, spectacular panoramas and a rare birdlife combine to attr

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

act outdoor enthusiasts from all over the world.

Popular ways of exploring the countryside is through hiking, and trekking by 4x4's or on the back of ponies. Renowned for their crafts and hospitality, the Basotho people offer a warm welcome when they say Khotso (peace), at the same time inviting you to e

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

xperience their tiny, traditional villages and the unspoilt serenity that is Lesotho...

CAPITAL:

Maseru

CLIMATE:

Temperate subtropical. Frost occurs frequently in winter. Most rain occurs Oct-Apr and is usually concentrated in fierce thunderstorms.

CURRENCY:

1 Lesotho Loti = 100 lisente. South Afric

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

n Rands are accepted. Visa, Access/MasterCard and Diners Club credit cards have limited acceptance and the use of traveller's cheques is limited outside Maseru.

ELECTRICITY:

220 volts, 50Hz. Plugs are 2- and 3-pin round.

HEALTH:

A yellow fever vaccination certificate is required from travellers coming

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

from infected areas. Visitors are also advised to take pre-arrival precautions against typhoid, hepatis A and polio. Other health concerns include minimal medical facilities; unavailability of many medicines; food- and water-borne illnesses, particularly amoebiasis, typhoid fever and cholera; influenza (

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

risk is May-Oct); AIDS; and tetanus.

LANGUAGE::

Sesotho and English

PUBLIC HOLIDAYS:

New Years' Day (1 Jan); Moshoeshoe (11 Mar); Heroes Day (4 Apr); Good Friday (9 Apr); Easter Monday (12 Apr); Labour Day (1 May); King's Anniversary (17 Jul); Independance Day (4 Oct); Christmas Day (25 Dec)

SHOPPING

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Basotho hat; grass woven items (mats, brooms, baskets); pottery; wool and mohair rugs; tapestries; textiles; rock painting reproductions; traditional seed, clay, bead and porcupine quill jewellery; silver, gold and ebony items; copperwork; African chess sets. The Basotho Hat Store is a good place to fin

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

d local crafts.

SOCIAL CONVENTIONS:

Main religions are Christianity and traditional African religions - these and the older generation should be respected. Normal courtesies and friendliness will be appreciated. Dress is casual, but modest. For business, dress in a lightweight suit and tie and observe u

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

sual formalities, but expect a casual atmosphere and pace.

TIME DIFFERENCE:

GMT +2

TIPPING::

Tipping is recommended at restaurants and hotels.

TOP TEN ATTRACTIONS DESCRIPTION:

Maseru and surrounds:

Basotho Hat, the principal handicrafts centre; the Catholic Cathedral of Our Lady of Victories; the P

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

pal Pavillion; Thorkild Hand Weaving and Moteng Weavers; Lancer's Gap, for views of the city and Caledon Valley; the Peach Blossom Route, in August explore the nearby orchards by car or on pony; Roma; Morija with its National Museum; and Matsieng featuring the Royal Summer Palace (closed to visitors).

Th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

aba-Bosiu:

Within easy reach of Maseru, a flat-topped hill features the substantial remains of the dwellings and villages of King Moshoeshoe I as well as the royal cemetery of Lesotho.

Teya-Teyaneng:

A short drive from Maseru, you can find a wide variety of souvenirs in this town whose weavers and craf

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tsmen sell their wares in the many craft centres available; close to the town are some San (Bushmen) rock art.

Malealea and surrounds:

The Gate of Paradise is a spectacular pass on the road to Malealea with panoramic views of the plains dotted with attractive traditional villages, in spring alpine flowe

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s alongside the road are in flower; an outstanding pony-trekking centre is available in Malealea and trekking or hiking routes include a number of waterfalls e.g. the Maletsunyane Falls and indigenous alpines such as the famous Spiral Aloe; nearby Mohale's Hoek is scenic and at nearby Motlejoeng visitors

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

can explore some of the most interesting cannibal caves, which are found throughout Lesotho.

Dinosaur Trackways:

About 5 miles north of Hlotse, Subeng Stream Dinosaur Trackway is one of the best examples of dinosaur trackways in Lesotho; the footprints of several different dinosaurs some dating back to

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

180-200 million years ago, are preserved in sandstone; the Moyeni and Masitise Dinosaur Trackways feature the footprints of many different dinosaurs as well as other primitive reptiles.

Ha Baroana Rock:

Paintings 39km east of Maseru; overhanging rock accessible after crossing a stream featuring a magnif

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

cent gallery of Bushmen paintings.

Molimo Nthuse and surrounds:

One of the most attractive tourist routes in Lesotho, the road to Molimo Nthuse includes a series of mountain passes, each offering superb vistas of mountain peaks, steep gorges, tumbling streams and broad valleys; at Molimo Nthuse you will

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

find one of the principal pony-trekking centres of Lesotho - on offer are treks for a couple of hours or days visiting waterfalls, local villages and other scenic attractions; travellers can visit the Maletsunyane Falls on a pony-trekking trail, it's impressive as the highest single-drop falls in souther

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

n Africa.

Katse Dam:

The centrepiece of the Highlands Water Project, the huge Katse Dam is spectacular when water levels are at their highest; the surrounding scenery is picturesque and activities cater for bird watchers and water sport enthusiasts.

Roof of Africa:

Scenic Route Via Sani Pass, the gate

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ay to the circuit; the greater part of the route lies in the Mokhotlong District, where the top of the Drakensberg Ridge is found; includes Thabana-Ntlenyana, which at 3482m is the highest peak in southern Africa; Sani Pass, Thaba-Tseka, Katse and Hlotse form an alternative section of the route where 4x4s

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

are most suited.

Sehlaba-Thebe National Park:

The park comprises 6500 hectares at an average elevation of 2400m and offers a wealth of birdlife and diverse Cape alpine flora; a small, minnow-like fish (Oreodaimon quathlambae) which was thought to be extinct has been rediscovered in the Tsoelikana River

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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