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Wouldn't it be great to turn back time? I'm tired of seeing older fighters past their prime, just looking for another payday. These guys are forced to figh

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t guys ten or fifteen years younger than themselves. The most recent examples of this were the fights between Tito Ortiz and Ken Shamrock and the fight bet

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

een Royce Gracie and Matt Hughes. We've also seen such mismatches as Tank Abbott vs Frank Mir and Tank Abbott vs Paul Buentello. Even so, part of me wants

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

o see these legends mix it up again, just not in mismatches which tarnish their past glory.

Let's face it, in their day, Gracie and Shamrock were the numb

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

er one and two fighters in the UFC and likely in the entire MMA world. Grace fought people 75 pounds heavier than he was and defeated them. Shamrock was fe

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

red for his power and leg locks. These two guys fought each other twice, the first time Ken Shamrock got caught in a choke from Gracie. The second match we

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

t past 25 minutes and was declared a draw.

I would personally like to see Ken Shamrock vs Royce Gracie 3. I have no interest in seeing either of these guy

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s tarnish their legendary status by fighting todays breed of MMA stars, but I'd love to see what they can do against each other.

While I'm at it, why not

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ull out a couple of other legends of the sport. How about Bas Rutten vs Mark Coleman. Some might argue that Mark Coleman is not in Bas' league. Maybe, but

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

hen Mark Coleman is in the right frame of mind, he's like a freight train, hard to stop!

Another interesting match up would be Kimo vs Don Frye. While nei

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

her of these two were my favorite fighters, Don Frye always puts on a show and the same can be said for Kimo. I think this would be a very exciting fight a

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nd interesting.

Okay, who could put on an MMA legends card without Tank Abbott? The only question with Tank is who is he going to fight? I'd love to see T

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

nk against Shamrock, or Frye. I don't think he'd stand a chance with Gracie. Of course Dan, the best Severn hasn't been mentioned yet, so let's put David "

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ank" Abbott vs Dan "The Beast " Severn on the card.

If "they" ever put together a legends card, those are the fighters I'd like to see on it.

Here's my p

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

icks

Ken Shamrock vs Royce Gracie
- With todays rules, Royce Gracie cannot wait around for something to happen. The pressure of rounds and the recove

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

y in between allows stronger fighters a couple of advantages. First, they can recuperate between rounds and secondly, they get stood back up. I think Ken w

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

uld win this fight, likely by decision.

Bas Rutten vs Mark Coleman
- Mark Coleman is tough, strong and a great wrestler, but Bas Rutten is a complete

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

fighter. His striking is better than Coleman and Bas knows submission fighting. Bas Rutten by submission.

Kimo vs Don Frye
- This one is a tough cal

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

, but if I need to I'll take Frye by decision. Never underestimate the pure toughness of Don Frye.

Tank Abbott vs Dan Severn
- While Tank is one of t

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e most exciting legend fighters there is, he is no match for Dan Severn who has managed to keep his skill(s) more up to date.

Here's to the legends of MMA

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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