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On the surface, improvisational comedy may seem to have little to do with business. Improv comedy is a form of theater where a group of performers take the stage with not

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

hing prepared in advance and use audience suggestions to instantly create comedy (as seen in the TV show, “Whose Line Is It Anyway?”). Business is…well, business.

In rea

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ity, business and improv have a great deal in common. An improv comedy show is a fast paced, unpredictable affair where anything can happen and things always change. Toda

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y’s business environment (especially today’s *small* business environment) is also a fast paced, unpredictable place where anything can happen and things always change.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

y applying the same principles that lead to success on an improv stage, business owners can maximize their productivity, reduce their stress, and flow with the unexpected

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

changes that inevitably occur.

Here are 5 quick tips from the world of improvisation that you can apply to your own business:

1) Take calculated risks
An im

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

prov show is inherently risky. You never know what the audience will do or say, and you never know what your fellow performers will do or say. Performers who play it safe

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

never succeed. Business is the same way. Playing it safe is a sure way to let the competition pass you by.

2) Focus on what you can control
When the unexpect

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ed happens (and it will), your first instinct may be to focus on the things outside of your control. You may focus on what someone else did, on what your competition is d

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ing, or on how you wish things were different. The only way to get anything done is to focus on and control the only thing you can control: yourself. You can’t control wh

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t happens, but you can control how you react to it.

3) Say “Yes, and…” instead of “Yes, but…”
People like to say “yes, but…” to pretty much everything. They

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

say it to other people, to new opportunities, and most of all to themselves. To succeed in improv or business, we all need to stay open minded, keep ourselves moving forw

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

rd, and keep creating new opportunities. The only way to do this is to say, “yes, and…” instead of “yes, but…”

4) Stay in the moment
One thing that kills imp

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rov comedy performances is when the performer focuses so hard on where he is going that he loses site of where he is. Having goals and a plan is great; slavish adherence

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

o that plan is deadly. Make sure you stay in the moment and pay attention to what is going on around you right now. This will improve your communication and productivity,

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

and allow you to react quickly to the unexpected.

5) Have fun
Bottom line: you can not perform improv comedy if you are not having fun. You can work without

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

having fun, but why would you want to? To be clear, by having fun I don’t mean goofing off or playing pranks. Having fun simply means enjoying what you do. Life is too sh

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rt to not have fun, but having fun is also a good business principles. People who enjoy themselves are more productive, better team members, and better leaders. There is

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

a time to be serious, but, to quote Stephen King, “Ask yourself frequently, ‘am I having fun.’ The answer needn’t always be ‘yes,’ but if it’s always ‘no,’ it’s time for

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

new career or project.”

There you have it. Five ideas from the world of improvisational comedy that can make your business more productive, less stressful, and more fun

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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