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Most of the articles I write on drug dangers are from extensive research. Well, this is one of those rare articles where I am speaking

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

from personal experience as well as research. The dangers of Advair are quite real. This drug for asthma almost killed me. The statis

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ics for related deaths are staggering. This article, along with explaining what Advair is and what it is used for, will also explain w

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y it's so dangerous. Hopefully, reading this will alert you to the possible dangers and help you to make an informed decision as to wh

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ther or not you want to use this drug for your allergies or asthma related breathing problems.

Advair is the brand name for the presc

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

iption drug salmeterol/fluticasone, which comes in the form of an inhalation disk. This drug is not a quick acting inhaler for asthma

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ttacks. It is used as a long term treatment for asthma and related breathing problems. It is also used as a long term treatment for va

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rious lung diseases.

The way Advair works is technically very simple. It decreases the swelling which is the major cause of most brea

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

hing problems and relaxes the surrounding muscles of the air passages. It is important to understand that Advair does not work right a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ay, and may take days or even weeks to show significant improvement.

Aside from the common minor side effects most associated with ta

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ing Advair, such as sore throat, headache, rapid heartbeat, nervousness and dry mouth, Advair can be fatal. Personally, when I was hav

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ng severe allergy problems, my doctor put me on Advair to help my breathing. Long story short, I had a serious reaction and was rushed

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

to emergency with severe difficulty breathing. Advair related deaths, in clinical controlled studies, were 13 in about 13,000. While o

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e tenth of a percent may seem small, the dangers are still quite real. Aside from the dangers of Advair reacting with other medication

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s, such as MAO inhibitors, Advair, even by itself, can be fatal.

The biggest problem with taking a drug like Advair is that most peop

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e won't know they're allergic to the active ingredients until it's too late, kind of like finding out you're allergic to peanuts by ea

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ing one. This is why it is my opinion that this drug is too dangerous to be prescribed so easily. In my own case, tests should have be

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

n conducted to see if there was a real potential for serious reaction. Certainly with today's technology, this has to be possible. But

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

we live in a world of prescribe first and revive the patient second.

Normally, I leave my personal feelings out of my reviews, but be

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ause of my personal experience with Advair, you need to be warned of the very real dangers of this drug.

To YOUR Health,

Steve Wagne

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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