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So you need ten sets of a fifty page document for this mornings meeting. It’s 8:30AM and your meeting is at 9:00AM. You begin with your project and the copier jams. You clear the jam but it keeps jamming! It’s not pulling in the paper. Sure you can call the repair person, bu

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t you need the copies now! There’s nothing you can do, or is there?

All office equipment that feeds paper has a component inside that pulls the paper out of the paper tray and into the machine. Most are made out of rubber and just like the tires on your car they wear out. Whe

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

a roller is worn and dirty they will cause paper jams. The purpose of this article is to show you how you can clean or rejuvenate the rollers long enough for you to complete your job and have your repair person come out and fix it properly.

Alternative solutions When y

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ur machine is jamming, first locate where the paper is jamming. Which paper tray? Is it tray 1 or tray 2? Also which size is jamming? On machines that have more than one paper tray you can switch paper trays and then you can skip cleaning the rollers. Make sure when you chang

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e cassettes that the copier registers the correct size. The machine will think it is a different size and it will jam. The sensors are set for a specific timing and it will know the difference in length from letter size and legal size. I also would try using the bypass tray or

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

manual feed tray if so equipped. This will get you up and running quicker than cleaning the rollers.

Determining if the rollers are the problem: If you need the specific tray to be functional we will get busy with the repair. First make a single copy in the tray that i

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

jamming. By doing this you are determining where the paper is jamming. If it is jamming in the exit for instance, you have another problem. If it is jamming in the center of the machine, again it is a different problem. But if it jams at the cassette or paper tray area the n

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ext step is removing the paper tray. Shine your flashlight into the paper feed area and see if there are any pieces of paper torn off inside or something blocking the paper path. Now that you have ruled out a blocked paper path, you can clean the feed roller(s).

Tools Requi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ed: Flashlight, strong cotton towel (so it will not rip off in the machine), WD-40 or Rubber roller rejuvenator. Note: Never use alcohol to clean rollers. It dries out the tread and the remaining tread will get ripped off and then it still will not feed. Use WD-40 it w

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rks great!

Cleaning the rollers: Shine your flashlight into the paper feed area and locate the rubber rollers that feed the paper in. Grab your towel and saturate it with cleaning fluid. This can be WD-40 or your favorite roller rejuvenator. Start by cleaning the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

oller and spinning it all the way around not missing any of the surfaces of the roller. Then go over it again with the dry part of the towel. As I said there are many different types. Some have a set of three rollers. One Pre-feed roller, this pushes the paper into the other

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

rollers. One feed roller and one separation roller. Others have a half moon style. These are harder to clean because they have a clutch system that keeps it at home position when not feeding.

WARNING: If you try and turn these to clean them you will damage the clutch

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

echanism! There are two ways you can clean these types. First you can actuate the clutch by pushing down on the solenoid or release lever. This sometimes can be hard to get to. You can also start the copy process and shut off the machine exactly when the feed roller engages.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

This takes some patience and practice but it is better than damaging the clutch. Once you get it where you can clean the roller repeat the procedure above.

Some alternatives to replacing feed rollers: There is a material called feed roller tape. I have used it when I

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

didn’t have the right roller in my car stock. It works with some styles mainly half moon styles. Just peel off the adhesive and wrap it around the worn roller surface. They also have some that stretch over the old rollers. I have never used this but I have been told it will get

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

you up and running. On old copiers or printers that you can no longer get parts for you can apply clear silicon on the feed surface and let it dry twenty four hours. It works but I am inclined to use the real thing. You can also use generic rollers manufactured for almost all

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

quipment. I have mixed feeling about these because I have had to go back and change them again later. For the best repair I use genuine OEM feed rollers. They are still inexpensive and they will last you longer and you will have fewer headaches.

Feed Rollers There are

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

many types of rollers and feed systems. Here are some common feed rollers with their part numbers. Rollers will normally come in a maintenance kit but they may need to be replaced approximately half way through the maintenance kit cycle.

HP LJ-4000 laser printer Feed

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ollers RG5-2651-000CN x 2 Note: These are very easily replaced. Just unsnap them and replace them with the new roller.

Toshiba E-Studio 350/450 Photocopier Paper Feed Rollers 44201807000 x2, 4400669910 Note: These take a little more work. First you need to remov

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

the paper feed assembly and then you can get to the clips that hold them on.

I hope this has helped you complete your print or copy job. Please remember that this article is just a quick fix and not a long term solution. Be sure and call your repair person to fix it correctly

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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